The PKUBC-WF is a prospective cohort study carried out in Weifang city of Shandong, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and child health. Data are collected regarding environmental, nutritional and lifestyle exposures as well as short-term and long-term health outcomes of mothers and their children from birth to before 18 years old. Biological samples including peripheral blood, urine, placenta, umbilical cord, cord blood, and faeces are also collected.
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Inclusion Criteria: * Pregnant woman 1. Pregnant women, 6-13\^+6 gestational weeks 2. Resided in Weifang in the past half years and have no plan to move out after delivery 3. Pregnant women who plan to have antenatal care and delivery in Weifang maternal\&Child Hospital. 4. Pregnant women who is willing to participate in this study with informed consent * Pregnant woman's husband 1. His wife was eligible for enrollment 2. He is the biological father of the child (his wife's current pregnancy) 3. Pregnant women's husband who is willing to participate in this study with informed consent * Offspring 4. Children born to pregnant women who met the inclusion criteria after enrolling in this study. 5\. Before the age of 8 years, his/her mother provided written informed consent. 6. After 8 years old, he/she agreed to continue this study and signed the informed consent. Exclusion Criteria: * Participants who cannot communicate normally.