1. Estimation of serum ceramides level in SLE patients as anovel marker for renal impairment 2. Correlation serum ceramides level with histological classification of LN,C3,C4,ANA,ANTI DS DNA ,CRP ,ESR , eGFR , creatinine /protein ratio 3. Follow up estimation of ceramides level in LN patients after 3 cycles of treatment
Inclusion Criteria: * Forty five patients will SLE with and without renal impairment diagnosed as SLE according to SLICC classification criteria for SLE Exclusion Criteria: * Malignant tumor ,infectious diseases, Alzheimer disease ,type 2 diabetes mellitus vitamin D intaker, obesty , cardiovascular disease (HTN,HF ,ischemic heart disease)