Obstructive Sleep Apnea Syndrome affect up 12% in adult population. It is associated with an increase rate of hypertension, metabolic syndrome, depression and adverse cardiovascular events. The evaluation of upper airway obstruction is vital to obtain site-specific treatment. Drug Induced Sleep Endoscopy (DISE) is a routinely exam which allows the direct observation of the upper airway during sedative induced sleep. Propofol and Dexmedetomidine are sedatives approved for all diagnostic examinations that required sedation.
Inclusion Criteria: * Apnea-Hypopnea Index (AHI) of 15-30. * Men and women, age 18-65 years, Body Mass Index (BMI) \< 35 Kg/m2, * Awake oxygen saturation \> 95% * Able to read and sign the consent form Exclusion Criteria: * Chronic Obstructive Pulmonary Disease (COPD) * Liver disease (Child Pugh 1-3) * History of chronic use of sedatives, narcotics, alcohol or illicit drugs, * History of 1st and 2nd degree heart block (not paced), * Left Ventricular Ejection Fraction (LVEF) \< 50%, * Allergy to propofol or Dexmedetomidine, * OSHAS (Obstructive sleep apnea/hypopnea syndrome) surgical failure patients * Pregnant women.