This research is being done to see if a drug called escitalopram (Lexapro) is helpful to people who are suffering from depression after traumatic brain injury (TBI).
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Inclusion Criteria: * Closed head injury * Fulfill Diagnostic and Statistical Manual Diploma in Social Medicine (DSM) IV criteria "Major Depressive Disorder" * 18 years of age or older * Able to provide informed consent * Stable medical history Exclusion Criteria: * History of Stroke, Encephalitis, Seizures, or any other pre-TBI neurological diseases * History of mental retardation * Alcohol or Substance dependence in the last 1 year * Inability to undergo MRI scan * Pregnancy * Current use of any psychotropic medications including any antidepressants, antipsychotics, anxiolytics, or sedative hypnotics * Poor response to escitalopram in the past * Acutely suicidal or requiring inpatient psychiatric hospitalization, as determined by the study psychiatrist * Good medication response to another antidepressant in the past