To determine the effect of increasing serum 25(OH)D from prevailing levels with vitamin D3 supplementation, while maintaining adequate calcium intake, on incidence of all-type cancer in a population sample of healthy postmenopausal women.
No linked publications found in PubMed
Inclusion Criteria: * Age: ≥ 55 years * Last menstrual period (LMP): ≥ 4 years * Good general health * Willingness to participate in this 4 year long study * Able to give informed consent * Able to live independently and travel to the Fremont Area Medical Center (FAMC) for study visits Exclusion Criteria: * History of cancer except * Superficial basal or squamous cell carcinoma of the skin * Other malignancies treated curatively more than 10 years ago * History of renal calculi or chronic kidney disease * History of sarcoidosis * History of tuberculosis * Participation in the previous Creighton cancer prevention study * Mini-Mental Status Exam (MMSE) score of ≤ 23. Use the MMSE if there are any concerns about the person's cognitive abilities or ability to give fully informed consent to the study. Concerns may be related to a person's lack of orientation to person, place, or time; language difficulties (inability to structure simple, complete sentences); or short term memory. The Hartford Institute for Geriatric Nursing recommends that a score of 23 or lower indicates cognitive impairment. (Accessed at www.harforddign.org). See appendix.